Gastrointestinal Malignancies
Conditions
Brief summary
This prospective cohort study investigates and compares the predictive power of two nutritional assessment tools, the Nutritional Risk Screening 2002 (NRS2002) and the Global Leadership Initiative on Malnutrition (GLIM) criteria. The study aims to determine how well these tools can predict postoperative complications in patients with gastrointestinal malignancies who are undergoing surgical resection.
Detailed description
Malnutrition is a common and severe problem in patients with gastrointestinal (GI) malignancies, adversely affecting surgical outcomes. This prospective cohort study was designed to evaluate and compare the predictive utility of two key nutritional assessment tools. Patients scheduled for elective curative-intent surgery for GI malignancies were enrolled. Within 24 hours of admission, each patient's nutritional status was assessed using both the Nutritional Risk Screening 2002 (NRS2002) and the Global Leadership Initiative on Malnutrition (GLIM) criteria. The study followed these patients through their hospital stay and post-discharge to collect data on the primary outcome of postoperative complications, as well as secondary outcomes including length of hospital stay, hospitalization costs, and unplanned 30-day and 60-day readmissions. The objective is to provide evidence to guide clinicians in using NRS2002 and GLIM for preoperative risk stratification and to identify patients who may benefit from nutritional interventions to improve surgical outcomes.
Interventions
None listed
Sponsors
Third central hospital of Tianjin affiliated Nankai university
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years. * Histopathologically confirmed primary gastrointestinal malignancy (e.g., esophageal, gastric, colorectal cancer). * Planned curative-intent surgical resection. * No prior anti-tumor treatments such as surgery, radiotherapy, chemotherapy, or immunotherapy for the current malignancy. * Provision of written informed consent to participate in the study.
Exclusion criteria
* Presence of other concurrent systemic malignant tumors. * Emergency surgery. * Hospital stay less than 48 hours post-surgery. * Incomplete critical clinical or nutritional data. * Refusal to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Postoperative Complications | Up to 30 days post-surgery | Measured as the number of patients experiencing one or more postoperative complications. Complications were defined and graded according to the Clavien-Dindo classification system and the Expert Consensus on Postoperative Complications Registration for Gastrointestinal Tumor Surgery (2018 Edition). Major complications were defined as Clavien-Dindo grade III or higher. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of Hospital Stay | Up to 60 days post-surgery (data collected at discharge) | The total duration of the index hospitalization, measured from the date of admission to the date of discharge. |
| Intensive Care Unit (ICU) Admission Rate | Up to 30 days post-surgery | The percentage of patients admitted to the ICU at any point during their postoperative hospital stay. |
| Unplanned 30-Day Readmission Rate | Within 30 days of discharge | The percentage of patients who had an unplanned hospital readmission for any reason. |
| Unplanned 60-Day Readmission Rate | Within 60 days of discharge | The percentage of patients who had an unplanned hospital readmission for any reason. |
Countries
China
Outcome results
None listed