Allergy
Conditions
Brief summary
Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of midazolam, ketamine and ondansetron. These drugs are FDA approved and commonly used before, during and after surgical procedures.
Interventions
DIAGNOSTIC_TESTSkin Testing
Participants will undergo skin prick testing and intradermal test injections at 5 increasing concentrations of midazolam, ketamine and/or ondansetron during one single study visit.
Sponsors
Mayo Clinic
Arizona Biomedical Research Commission (ABRC)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Not have a history of an adverse reactions to midazolam, ketamine or ondansetron * Ability to understand study procedures and to comply with them for the entire length of the study. * Contraception is not necessary, and we will include women of reproductive capability.
Exclusion criteria
* Unstable patients. * History of any adverse reaction (allergy or sensitivity) to midazolam, ketamine or ondansetron. * Pregnant and Pediatric patients * Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron. | 1 Day | Determine the maximal nonirritating concentrations of midazolam, ketamine and ondansetron |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Skin Testing Results | 1 Day | Determine the frequency of false positive test results in patients who have received Midazolam, Ketamine or Ondansetron in the past. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAlexei Gonzalez Estrada, MD
Mayo Clinic
Outcome results
None listed