Chronic Kidney Disease, Sarcopenia
Conditions
Keywords
Sarcopenia, Chronic kidney disease, Protein intake, Nutrition
Brief summary
The goal of this clinical trial is to determine whether increasing protein intake in elderly adults with pre-dialysis chronic kidney disease, in combination with resistance exercise, improves muscle mass without worsening renal function.The main questions it aims to answer are: * Does a protein intake of 1.2 g/kg BW/day combined with exercise improve muscle mass better than a protein intake of 1.0 g/kg BW/day? * Does a protein intake of 1.2 g/kg BW/day combined with exercise lead to greater improvements in muscle strength and function? * Does a protein intake of 1.2 1.2 g/kg BW/day combined with exercise cause a decline in renal function (eGFR) compared to a protein intake of 1.0 1.2 g/kg BW/day? Researchers will compare a group assigned to intake 1.2 g/kg BW/day of protein with another group assigned to intake 1.0 g/kg BW/day, to assess whether the higher intake improves muscle mass and physical performance without causing harm. Participants will * be assessed for body composition, physical performance and nutritional intake. * be assigned to consume protein at either 1.2 or 1.0 g/kg/day. * perform a home-based resistance exercise program using resistance bands. * provide blood and urine sample to monitor renal function. * visit the clinic at weeks 12 and 24 for repeated measurement.
Interventions
BEHAVIORALProtein intake 1.2 g/kg/day and resistance exercise
Protein intake of 1.2 g/kg/day in combination with resistance exercise using resistance bands
BEHAVIORALProtein intake 1.0 g/kg/day and resistance exercise
Protein intake 1.0 g/kg/day in combination with resistance exercise using resistance bands
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Thai adults aged ≥ 65 years * Chronic kidney disease with estimated glomerular filtration rate (eGFR) 30-59 ml/min/1.73 m2 * Sarcopenia or presarcopenia (diagnosis based on Asian Working Group for Sarcopenia (AWGS) 2019 definition)
Exclusion criteria
* Active cardiopulmonary disease(s) or uncontrolled hypertension with contraindications to resistance training * Physically or cognitively unable to participate in the resistance exercise program (e.g. dementia), as determined by the attending physician * Limitations of body measurements and interpretation using Bioelectrical Impedance Analysis (BIA) e.g. presence of pacemaker, surgical metal implants * Meets the definition of AKI or AKD, defined as alterations in kidney function within the past 3 months * Severe vitamin D deficiency (25-OH Vitamin D level \< 10 ng/mL) * Refuses to give consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Between-Group Differences in Muscle Mass Changes at 6 Months | From enrollment to the end of intervention at 24 weeks |
Countries
Thailand
Outcome results
None listed