Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers, Inflammatory Mediators
Conditions
Keywords
Bio-C Temp, Calcium Hydroxide, Intracanal medicament, Matrix Metalloproteinase 9, Biomarkers, Post operative pain
Brief summary
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: * Intensity of postoperative pain * levels of MMP -9 in Periapical Fluids.
Interventions
Bio-C Temp Bioceramic intracanal dressing in the form of injectable premixed paste
Calcium Hydroxide intracanal dressing in the form of injectable premixed paste
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Age between 18-50 years old. 2. Males and females. 3. Healthy patients categorized as I or II according to The American Society of Anesthesiologists. (ASA I or II), with no underlying allergies. 4. Single-rooted mandibular premolar teeth, having single root canal: * Diagnosed clinically with pulp necrosis. * Absence of spontaneous pulpal pain. * Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2\*2 mm radiographically. 5. Patients accepting to participate in the trial. 6. Patients who can understand pain scale and can sign the informed consent
Exclusion criteria
1. Medically compromised patients having significant systemic disorders (ASA III or IV). 2. Pregnant females. 3. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception. 4. Teeth with multiple canals. 9 5. Teeth that show association with acute periapical abscess, swelling or fistulous tract. 6. Teeth with vital pulp. 7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam. 8. Immature teeth. 9. Teeth with greater than grade I mobility or pocket depth greater than 4 mm. 10. Teeth showing radiographic evidence of external or internal root resorption, vertical root fracture, perforation or calcification. 11. Patients with two or more adjacent teeth requiring endodontic treatment. 12. Patients reporting bruxism, clenching or TMJ problems. 13. Inability to perceive the given instructions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intensity of post-operative pain | 6 hours post-instrumentation | Intensity of post-operative pain as measured by Numerical Rating Scale (NRS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Periapical MMP-9 level | at the first visit post- instrumentation | Level Of MMP-9 Enzyme in the periapical tissue fluid, quantified by ELISA |
| Periapical MMP-9 Level | After 1 week at the second visit (pre-obturation) | Level of MMP-9 enzyme in the periapical tissue fluid, Quantified by ELISA |
Outcome results
None listed