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Carbohydrate Mouth Rinsing and Cognitive Response During Exercise

Carbohydrate Mouth Rinsing Enhances Prefrontal Cortex Oxygenation and Cognitive Performance, Reducing Perceived Exertion During High-Intensity Exercise

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07099807
Enrollment
11
Registered
2025-08-01
Start date
2025-02-28
Completion date
2025-05-17
Last updated
2025-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Performance of Fit Athletes

Brief summary

This study investigates whether rinsing the mouth with a carbohydrate solution can improve brain oxygenation and cognitive function during high-intensity exercise. Eleven trained cyclists participated in multiple exercise sessions under different mouth rinse conditions. Brain oxygenation, perceived exertion, and cognitive performance were measured. The goal is to understand if this simple technique can support both physical and mental performance during demanding exercise.

Interventions

A 6.4% maltodextrin solution (64 g/L) was prepared using Nutricost Maltodextrin Powder. Participants performed five mouth rinses per trial, each using 25 mL of the solution for 10 seconds before expectorating. Each rinse was followed by a 30-second rest. Participants were instructed not to swallow the solution. Rinsing procedure was standardized across all sessions.

A placebo solution containing 0.05 g/L of non-caloric sucralose in distilled water was used to match sweetness and viscosity of the CHO-MR. Participants performed five rinses of 25 mL for 10 seconds each, spitting out the solution after each rinse. 30-second rest intervals followed each rinse. Swallowing was not allowed. Rinse frequency, volume, and duration were standardized.

BEHAVIORALMusic Listening

Participants listened to high-tempo music (120 bpm) for 15 minutes before exercise using standardized earbuds. Music was selected from a public YouTube playlist titled 120 BPM Best Dance Music for Running and Working Out. Volume was calibrated at 65 dB (50% of max device volume). Auditory conditions were standardized across all participants.

Sponsors

CHA University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* Aged between 20 and 30 years * Engaged in regular cycling training (≥5 sessions per week, \ 4 hours per day) * No known cardiovascular, neurological, or metabolic diseases * Provided written informed consent

Exclusion criteria

* Current use of medication affecting cardiovascular or cognitive function * Recent musculoskeletal injuries that affect cycling ability * Smoking or excessive alcohol consumption * Refusal or inability to comply with study procedures

Design outcomes

Primary

MeasureTime frame
Changes in prefrontal cortex oxygenation (ΔO2Hb)Immediately post-intervention and post-time trial (within same day)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026