Hyperparathyroidism, Primary, Parathyroid Adenomas
Conditions
Keywords
Parathyroid adenomas, Rubidium-82
Brief summary
Assess the uptake of rubidium-82 in parathyroid adenomas.
Detailed description
Parathyroid adenomas demonstrate uptake of rubidium-82 chloride and can be detected with PET imaging. The investigators aim to describe the uptake pattern of rubidium-82 chloride in parathyroid adenomas as well as compare the uptake pattern of rubidium-82 chloride to that of 18F-fluorocholine in patients with parathyroid adenoma.
Interventions
OTHERPET/CT imaging with rubidium-82
PET imaging of the neck will be started immediately before infusion of 10 Megabecquerels per kilograms of rubidum-82 over 30 seconds. The acquisition will last 10 minutes. This will be followed by a non-contrast low-dose CT of the neck for localization and attenuation correction.
Sponsors
Matthieu Pelletier-Galarneau, MD MSc
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18y 2. Ability to undergo imaging logistics 3. Ability to provide informed consent 4. Biochemical evidence of primary hyperparathyroidism 5. Documented parathyroid adenoma on prior 18F-fluorocholine imaging
Exclusion criteria
1. Normocalcemic primary hyperparathyroidism 2. Breastfeeding or pregnancy 3. Claustrophobia or inability to undergo imaging logistics 4. Any other history, condition, therapy, or uncontrolled intercurrent illness, which could in the opinion of the investigator affect compliance with study requirements or which would make the participant unsuitable for this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uptake pattern of rubidium-82 in parathyroid adenomas | 3 months | Rudibium-82 uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between the uptakes of rubidium-82 and 18F-fluorocholine in patients with parathyroid adenomas | 3 months | Radioactive tracer uptake will be compared between Rudibium-82 and 18F-Fluorocholine. Uptake will be assessed using Maximum Standardized Uptake Value (SUVmax) and target-to-background ratios (TBR). TBR is calculated by dividing a lesion SUVmax by the mean SUV (SUVmean) or the blood pool. Maximum Standardized Uptake Value (SUVmax) and target-to-background (TBR) will be presented as median with interquartile range as well as minimum and maximum values. |
Countries
Canada
Contacts
Primary ContactMatthieu Pelletier-Galarneau, MD MSc
Backup ContactPelletier-Galarneau
Outcome results
None listed