Hyperbilirubinemia
Conditions
Brief summary
The study aimed at filling the gaps by evaluating the effectiveness of vitamin-D as an adjuvant to phototherapy in reduction of indirect serum bilirubin among neonates with exaggerated physiological hyperbilirubinemia.
Detailed description
If vitamin-D has been found effective as an adjuvant to phototherapy in the treatment of exaggerated physiological hyperbilirubinemia, it may help to reduce the serum bilirubin level rapidly. It may also reduce the complications by shortening the duration of phototherapy to offer better patient compliance and better patient outcomes.
Interventions
DRUGVitamin D3
Neonates were given vitamin D3 (cholecalciferol) in an oral drops formulation (400 IU/drop), at a dose of 400 IU once a day until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours as an adjuvant therapy to phototherapy.
PROCEDUREPhototherapy
Neonates received only phototherapy until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Days to 8 Days
Healthy volunteers
No
Inclusion criteria
* Newborns of any gender * Age of 3rd day of life to 8th day of life * Gestation age ≥37 to ≤42 weeks * Total serum bilirubin level more than 12.9 mg/dL * Weight \> 2.5 kg
Exclusion criteria
* Congenital defects (on physical examination) * Large for gestational age infant * Rh Incompatibility (were excluded on basis of blood grouping of mother and baby) * ABO Incompatibility (were excluded on basis of blood grouping of mother and baby) * Neonatal sepsis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bilirubin reduction comparison | 72 hours | Net reductions in bilirubin levels in two groups after 72 hours were compared. |
Countries
Pakistan
Outcome results
None listed