Septic Shock
Conditions
Keywords
sepsis, anaerobic metabolism
Brief summary
The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.
Detailed description
The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to compare the kinetics of the PvCO2-PaCO2/CaO2-CvO2 ratio with a classic marker of anaerobic metabolism (arterial lactate) in the early phase of septic shock.
Interventions
DIAGNOSTIC_TESTPvCO2-PaCO2/CaO2-CvO2 ratio
Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).
Sponsors
Avicenna Military Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). \[Sepsis 3 criteria\]
Exclusion criteria
* Absence of central venous access. * Central venous access not positioned in the superior vena cava (e.g., femoral access).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prognostic value of PvCO2-PaCO2/Ca O2-CvO2 in patients with septic shock | From patient inclusion (baseilie = H0) then at H2, H6, H 12 and H24 (H = hours) | The ability of PvCO2-PaCO2/Ca O2-CvO2 to predict mortality in patients with septic shock. These biological values will be measure using arterial and central venous blood gaz. |
Countries
Morocco
Contacts
CONTACTYounes Aissaoui Professor of critical care medicine
CONTACTAyoub Belhadj Professor of critical care medicine
PRINCIPAL_INVESTIGATORYounes Aissaoui Pr
Cadi Ayyad University. Faculty of Medicine and Pharmacy. Avicenna Military Hospital.
Outcome results
None listed