Diabetic Retinopathy (DR), Visual Perception
Conditions
Brief summary
Investigators aim to investigate the effectiveness of visual perceptual learning on visual perceptual function in participants with diabetic retinopathy and to provide novel therapeutic insights for visual functional rehabilitation in diabetic retinopathy.
Interventions
PROCEDUREvisual perceptual learning
Participants in the VPL group performed 40 minutes of daily monocular training at home for three months, with follow-up evaluations conducted at 1 month and 3 months after training initiation.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* moderate to severe non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy(PDR) prior to treatment(17) * prior pan retinal laser photocoagulation (PRP) at least 4 weeks before enrollment or vitreoretinal surgery at least 8 weeks before enrollment * stable clinical condition * best-corrected visual acuity (BCVA) \> 1.0 logMAR (equivalent to a Snellen visual acuity of \< 20/200) * clear refractive media * age ≤ 65 years * ability to comprehend the examination and training procedures
Exclusion criteria
* significant refractive media opacity * psychiatric disorders, chronic alcoholism and traumatic brain injury * new-onset vitreous hemorrhage, myopia, strabismus, amblyopia, glaucoma and macular diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| contrast sensitivity | From enrollment to the end of treatment at 12 weeks | The contrast sensitivity measurements include grating acuity, first-order motion stimulus perception sensitivity, second-order stationary stimulus perception sensitivity and second-order motion stimulus perception sensitivity, which represent the reciprocal of the contrast threshold. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Low Vision Quality of Life Questionnaire | From enrollment to the end of treatment at 12 weeks | This instrument has demonstrated high reliability and validity, and is sensitive to changes in visual function among individuals with vision loss. The minimum value is 25 and the maximum value is 125. Higher scores indicate better quality of life. |
Other
| Measure | Time frame | Description |
|---|---|---|
| The Hospital Anxiety and Depression Scale | From enrollment to the end of treatment at 12 weeks | The scale aims to measure anxiety and depression levels in hospital patients with high reliability and validity. The Hospital Anxiety and Depression Scale (HADS) provides separate scores for anxiety (HADS-A) and depression (HADS-D), each ranging from 0 to 21. A lower score indicates a lesser degree of anxiety and depression. |
Countries
China
Outcome results
None listed