Analgesia, Obstetrical, Cesarean Delivery, Postoperative Pain
Conditions
Brief summary
The goal of this clinical trial is to compare intrathecal bupivacaine with or without morphine for postoperative analgesia in patients undergoing elective cesarean section. The main questions it aims to answer are: Is intrathecal bupivacaine with morphine superior to intrathecal bupivacaine alone for postoperative analgesia for parturients undergoing cesarean section? What is the duration of analgesia in the two groups? Researchers will compare drug intrathecal bupivacaine with morphine to a iintrathecal bupivacaine alone to see if intrathecal morphine has benefits for psotoperative analgesia . Participants will: Get intrathecal bupivacaine with Morphine or intrathecal bupivacaine alone during spinal anesthesia for cesarean section. They will be followed up for NRS pain scores and side effects for 24 hours. Time to need of first rescue analgesic will be noted
Interventions
Participants will receive 100 mcg intrathecal morphine along with 2.2ml of 0.5% hyperbaric bupivacaine
0.5% hyperbaric Bupivacaine 2.2 ml
Sponsors
Tribhuvan University Teaching Hospital, Institute Of Medicine.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Parturients undergoing elective caesarean section under Spinal anesthesia * ASA PS II, III * \> 18 years
Exclusion criteria
* Refusal to Participate * Contraindications to spinal anaesthesia and adjuvants INR ≥ 1.5 Plateletes \< 1,00,000/cumm Severe aortic stenosis, and/or severe mitral stenosis Infection at lumbar puncture site Known allergy to local anesthetics and opioids * Communication barrier * Height \<150 cm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to need of first rescue analgesic | within 24 hours | time of spinal anesthesia to time of demand of first rescue analgesic |
| NRS score | 24 hours | comapre NRS score at 0,1,6,12,18,24 hours between the groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24 hours analgesic consumption | 24 hours | consumtion of total analgesic in first 24 hours |
Outcome results
None listed