Full Assessment of Clinical Transfusion Support

An Assessment of Hematologic Diseases Among Blood Transfusion Recipients and Donated Units at a Pediatric Regional Referral Hospital in Uganda

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07094646

Acronym

FACTS

Enrollment

250

Registered

2025-07-30

Start date

2023-09-21

Completion date

2024-03-19

Last updated

2025-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Transfusion, Malaria Parasitaemia, Sickle Cell Anemia

Keywords

FACTS, JRRH, sickle cell anemia

Brief summary

This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive. Researchers are using small samples of dried blood (called dried blood spots) from both the children and the donated blood to find out what might be causing the anemia.

Detailed description

This study includes children at Jinja Regional Referral Hospital (Jinja, Uganda) who need a blood transfusion, whether they are in the clinic, emergency room, or children's ward. After doctors finish the usual blood tests, a small sample of leftover blood will be saved on a special card (called a dried blood spot). The same will be done for all blood transfused during the study. These samples will be frozen and later sent to Cincinnati Children's Hospital for testing.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Children receiving a blood transfusion in Eastern Uganda at Jinja Regional Referral Hospital.

Exclusion criteria

* If receiving a blood transfusion, refusal or inability to sign an informed consent.

Design outcomes

Primary

Measure	Time frame	Description
Frequency of Sickle Cell Anemia	At enrollment.	How common sickle cell anemia is in children who need a blood transfusion in Eastern Uganda.

Secondary

Measure	Time frame	Description
Frequency of Malaria Parasitemia	At enrollment.	How common malaria parasitemia in children needing blood transfusions in Eastern Uganda.
Frequency of Iron Deficiency	At enrollment	How often people who get blood transfusions have low iron levels, and the iron levels in the blood that is donated and used for transfusions
Blood Group Markers	At enrollment.	Checking to ensure safe blood matches from donated blood and people receiving blood transfusions.

Countries

Uganda

Outcome results