Healthy, Substance Use
Conditions
Keywords
Functional magnetic resonance imaging (fMRI), Questionnaires, Interviews, Behavioral tasks
Brief summary
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
Interventions
DEVICEfMRI
Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.
BEHAVIORALQuestionnaires and surveys
Participants will have multiple visits during this study and fill out various surveys at these visits.
BEHAVIORALBehavioral tasks and eye tracking
Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.
Sponsors
University of Michigan
National Institute on Drug Abuse (NIDA)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
This is a longitudinal, repeated-measures, naturalistic study that will take place at the University of Michigan.
Eligibility
Sex/Gender
ALL
Age
18 Years to 22 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-22 years old at baseline * Right-handed * Medically/physically able to give informed consent * English-speaking * Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
Exclusion criteria
* Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine) * History of psychosis in self or first-degree relative * Current treatment for substance use disorder * Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication) * Intelligence quotient (IQ) \< 70 * Lifetime history of head trauma with loss of consciousness \> 5 minutes * Reliance on glasses to be able to read small text at a distance of approximately 30 inches * Colorblindness * MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score | Baseline | PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN) | Baseline | PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with the first principal component of average parameter estimates from the following regions extracted for the cannabis vs. neutral contrast: ventral striatum, anterior cingulate, posterior cingulate, insula, amygdala, orbitofrontal cortex, inferior occipital cortex, and inferior parietal cortex |
Countries
United States
Contacts
CONTACTPaul Holdefer, MPH
PRINCIPAL_INVESTIGATORLora Cope, PhD
University of Michigan
Outcome results
None listed