Cord Blood, Metabolomics
Conditions
Keywords
cord blood, metabolomics
Brief summary
Birth type is closely linked to fetal and maternal stress responses. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.
Detailed description
Birth type is closely linked to fetal and maternal stress responses. Previous studies have found higher levels of hormones associated with stress responses in mothers who delivered vaginally compared to those who delivered by cesarean section (C/S). Similarly, differences in markers assessing stress responses in newborns have been observed based on delivery method. However, the literature lacks sufficient studies on low-molecular-weight metabolites, which reveal the metabolic status of newborns. Metabolomic profiling studies are introductory studies that provide comprehensive information about cell or organism metabolism. They contribute to research in many areas of medicine. In perinatology, metabolomic profiling studies have been conducted on topics such as neural tube defects, intrauterine growth restriction, and maternal diabetes. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.
Interventions
None listed
Sponsors
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* 1\) Female patient aged 18-35 2) Term pregnancy 3) Pregnant with follow-up
Exclusion criteria
* 1\) Having been diagnosed with diabetes mellitus before or during pregnancy 2) Having been diagnosed with hypertension before or during pregnancy 3) Non-singleton pregnancy 4) Non-elective C/S 5) Fetal intrauterine growth restriction 6) Mothers and their babies with a fetal birth anomaly or suspected birth anomaly will not be included in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cord blood metabolomic analysis | From enrollment to birth. Cord Blood is taken during birth | Cord blood samples will be analysed via LC/MS analysis |
Countries
Turkey (Türkiye)
Outcome results
None listed