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Early Detection of Supraclavicular Brachial Plexus Block Failure Using Infrared Thermography and Perfusion Index

Early Detection of Supraclavicular Brachial Plexus Block Failure Using Infrared Thermography and Perfusion Index: Randomized Double-Blind Controlled Study

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07092891
Enrollment
80
Registered
2025-07-30
Start date
2025-08-15
Completion date
2026-09-01
Last updated
2025-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brachial Plexus Blocks, Regional Anaesthsia

Keywords

Brachial Plexus Blocks, Regional Anaesthesia

Brief summary

Successful peripheral nerve blockade is fundamental to modern regional anesthesia, particularly for upper limb surgeries. Ensuring the efficacy of a nerve block early in the perioperative period is critical, as delayed recognition of block failure may lead to intraoperative pain, the need for additional sedation or general anesthesia, and overall poorer patient outcomes. Conventional methods for assessing block success, such as sensory testing with pinprick or cold stimuli and motor assessment using strength scales, require patient cooperation and often take 15-30 minutes to yield definitive results. These delays are especially limiting in fast-paced surgical environments or when early decisions regarding anesthesia management are necessary. Emerging non-invasive monitoring technologies offer promising alternatives for the early, objective assessment of block efficacy. Infrared Thermography (IRT) measures skin surface temperature, which increases due to sympathetic nerve blockade-induced vasodilation.

Detailed description

Successful peripheral nerve blockade is fundamental to modern regional anesthesia, particularly for upper limb surgeries. Ensuring the efficacy of a nerve block early in the perioperative period is critical, as delayed recognition of block failure may lead to intraoperative pain, the need for additional sedation or general anesthesia, and overall poorer patient outcomes. Conventional methods for assessing block success, such as sensory testing with pinprick or cold stimuli and motor assessment using strength scales, require patient cooperation and often take 15-30 minutes to yield definitive results. These delays are especially limiting in fast-paced surgical environments or when early decisions regarding anesthesia management are necessary. Emerging non-invasive monitoring technologies offer promising alternatives for early, objective assessment of block efficacy. Infrared Thermography (IRT) measures skin surface temperature, which increases with sympathetic nerve blockade-induced vasodilation. Perfusion Index (PI), derived from pulse oximetry, reflects peripheral perfusion and also rises as vascular tone decreases following a successful nerve block. Both IRT and PI provide quantifiable, real-time physiological markers of sympathetic and circulatory changes that precede full sensory or motor blockade. Although several studies support their individual utility, there is limited evidence on their combined predictive value or their integration into routine clinical practice. Further investigation is needed to validate their role in enhancing the accuracy and timeliness of block assessment.

Interventions

PROCEDUREUltrasound-Guided Supraclavicular Block

Ultrasound-guided supraclavicular brachial plexus block using a high-frequency linear ultrasound probe-real-time visualization of the brachial plexus for precise anesthetic delivery.

30 mL used for supraclavicular brachial plexus block

DEVICEUltrasound

Imaging for block placement

DEVICEInfrared Thermography Camera

Skin temperature monitoring

DEVICEPulse Oximeter

Perfusion Index monitoring

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Adults aged 18-70 years * ASA Physical Status I-III

Exclusion criteria

* General * Coagulopathy * Allergy to local anesthetics * Special * Neurological deficits in the affected limb * Peripheral vascular disease or Raynaud's phenomenon * Infections or skin lesions at the site of injection * Use of a tourniquet

Design outcomes

Primary

MeasureTime frameDescription
Change in Skin Temperature (°C) Measured by Infrared Thermography From Baseline to 10 Minutes Post-block.Baseline, 5, and 10 minutes post-injectionMean change in skin temperature on the operative limb captured using infrared thermography at defined time points.
Change in Perfusion Index From Baseline to 10 Minutes Post-blockBaseline, 5, and 10 minutes post-injectionPI measured via pulse oximeter; change calculated as ratio to baseline values.

Secondary

MeasureTime frameDescription
Correlation Between Changes in Skin Temperature and Perfusion Index With Sensory and Motor Block Scores at 20 Minutes20 minutes post-injectionCorrelation between physiologic changes and clinical assessments of sensory and motor block success using pinprick/cold test and Modified Bromage Scale.

Contacts

Primary ContactTarek Ashraf Ibrahim Abd Al-Hafiz, resident doctor
tarek.15235463@med.aun.edu.eg+201092002284

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026