Left Ventricular Function, Melatonin, Neonates, Persistent Pulmonary Hypertension
Conditions
Brief summary
This study aimed to evaluate the effect of melatonin on the left ventricular function in neonates with persistent pulmonary hypertension
Detailed description
Persistent pulmonary hypertension of the newborn (PPHN) is a potentially deadly disorder in which the circulation of the fetus is unable to adjust to the extrauterine environment. Persistently high pulmonary pressures may cause right-to-left shunting, hypoxia, and right ventricular failure. Melatonin, a neurohormone produced by the pineal gland, offers an exceptional defense against reactive oxygen species (ROS). Infants are unable to synthesize melatonin during their first few weeks of life, which may exacerbate oxidative stress in hypoxic conditions. Additionally, Melatonin's antioxidative capabilities have been shown in neonatal pulmonary and respiratory disorders.
Interventions
DRUGMelatonin
Neonates were given Melatonin.
OTHERPlacebo
Neonates received placebo.
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
36 Weeks to No maximum
Healthy volunteers
No
Inclusion criteria
* Neonates of ≥ 36 weeks of gestational age. * Both sexes. * Admitted with persistent pulmonary hypertension.
Exclusion criteria
* Preterm infants \< 36 weeks of gestation. * Infants with congenital heart diseases. * Infants with dysrhythmia. * Chromosomal abnormalities. * Severe pathological jaundice. * Metabolic or endocrinal disorders. * Major congenital malformations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricle global longitudinal strain | Immediately after medication (Up to 1 hour) | Left ventricle global longitudinal strain (LV-GLS) was recorded. |
Countries
Egypt
Outcome results
None listed