Knee Osteoarthristis
Conditions
Keywords
Hyaluronic acid, osteoarthritis, pain, disability
Brief summary
The purpose of the study is to determine the effects of HA, PRP and the combination of HA and PRP in reducing pain and improving functional disability in patients with knee osteoarthritis.
Detailed description
To determine the effects of combination of platelet rich plasma (PRP) and hyaluronic acid and the PRP or HA alone in reducing pain and increasing range of motion among individuals with knee osteoarthritis.
Interventions
DRUGHyaluronic Acid (HA)
Hyaluronic Acid
DRUGPlatelet Rich Plasma
Platelet rich plasma
Hyaluronic Acid and Platelet rich plasma
Sponsors
University of Karachi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Single blinded study, only the assessor was kept blinded
Intervention model description
Participants were randomly divided into three groups. Twenty cases (Group A) were injected with HA, 20 (Group B) had PRP, and the remaining 20 (Group C) received a combination of HA and PRP
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* grade II-III according to the Kellgren-Lawrence classification), * pain or functional limitations in patients' activity of daily living before the treatment, * age between 40 and 70 years of age, and the absence of clinical or imaging signs of articular instability.
Exclusion criteria
* includes known hypersensitivity to hyaluronic acid, * pregnancy and lactation, a BMI greater than 40 kg/m2, * chronic administration of anticoagulant drugs or a history of coagulopathies, * neoplastic lesions, and knee or kidney failures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| visual analogue scale | Recorded before the treatment and repeated within 3 and 6 months after the treatment. | It is a straight line, 100 millimeters long line, one end of the line means not at all or none and the other end means the worst possible or extremely. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) | Recorded before the treatment and repeated within 3 and 6 months after the treatment. | It s a questionnaire used to assess pain, stiffness, and physical function in individuals with osteoarthritis, particularly of the knee. It is a self-administered, multidimensional tool that evaluates these three dimensions through a series of questions, typically on a Likert scale. |
Countries
Pakistan
Outcome results
None listed