Feeding Disorders, Lactase Deficiency, Congenital, Premature
Conditions
Brief summary
This study aims to study the effect of lactase enzyme in preventing feeding intolerance in preterm neonates in neonatal intensive care unit at Alexandria University Children's Hospital.
Interventions
DRUGlactase administration
1 drop for each 10 ml of formula milk for 14 days
OTHERplacebo
10 ml milk without lactase
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Days to 1 Months
Healthy volunteers
No
Inclusion criteria
will be as follows: * Preterm neonates ≤ 32 weeks gestational age. * Start feeding in the first 72 hours of life. 8.
Exclusion criteria
Patients with any of the following will be excluded: 1. Parental consent lacking/refusal. 2. Obvious major congenital abnormalities. 3. Infants more than 72 hours of age at the time of randomization. 4. Delayed introduction of feeding (beyond three days of life). 5. Known galactosemia. 6. Severe IUGR. -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feeding intolerance: | first two weeks of life | vomiting number per day aspirates in ml/day abdominal distension by measuring abdominal circumference before and after feeds |
Countries
Egypt
Contacts
CONTACTMarwa M Farag, PhD
Outcome results
None listed