Post Operative Analgesia, Spinal Anesthesia
Conditions
Keywords
Adjuvants, Sub-Arachnoid Block, C-section
Brief summary
Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.
Detailed description
To prolong the duration of Sub-Arachnoid block number of drugs which are known as adjuvants can be used. One of the commonly used adjuvant is Dexamethasone a steroid given by intravenous route having anti-emetic and anti-inflammatory effect. This drug also prolongs the duration of Sub-Arachnoid block which can be helpful in case of lengthy surgical procedure and also extends the duration of analgesia in the post operative period.
Interventions
DRUGDexamethasone
Immediately after sub-arachnoid block 8mg of Dexamethasone will be administered intravenously
DRUGPlacebo
2ml of Normal saline will be given intravenously immediately after administration of spinal anesthesia
Sponsors
Rawalpindi Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists (ASA) class: II and above. * Elective Cesarean section under Spinal Anesthesia.
Exclusion criteria
* Gestational diabetes * Body mass index \>35 kg/m2 * Diabetes mellitus * Adrenal insufficiency * Chronically receiving steroids * Allergic to study medications * Sensory block level less than T4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time for block to regress by two dermatomes in post operative period | This will be the time in minutes from end of C section in post operative period for the block to regress by two dermatomes |
Secondary
| Measure | Time frame |
|---|---|
| Time to rescue analgesia | This will be the time in minutes from the end of Cesarean section in the post operative period to first rescue analgesia. |
Countries
Pakistan
Contacts
Primary ContactHuda Tariq, MBBS
Outcome results
None listed