CT-Based Scoring System to Predict Surgical Need in Tracheal Stenosis (TSMAS Study)

Development of a CT-Derived Risk Score to Guide Treatment Decision: Tracheal Stenosis Morphology and Attenuation Score (TSMAS)

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07086729

Enrollment

Registered

2025-07-25

Start date

2025-09-01

Completion date

2026-01-30

Last updated

2025-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tracheal Stenosis

Keywords

Tracheal Stenosis, Postintubation Stenosis, Hounsfield Unit, Morphologic Scoring, Computed Tomography

Brief summary

This study aims to develop a CT-based scoring system to help predict whether patients with tracheal stenosis will require surgical treatment or can be managed with endoscopic procedures. Using retrospective data, researchers will evaluate CT scans of patients diagnosed with tracheal stenosis to measure features such as airway diameter, wall thickness, and tissue density (measured in Hounsfield Units). The goal is to create a non-invasive, reproducible, and objective tool-called the Tracheal Stenosis Morphology and Attenuation Score (TSMAS)-that can support clinical decision-making and improve treatment planning.

Interventions

OTHERCT-Based Morphologic and Attenuation Scoring

Retrospective analysis of CT images to extract morphological and Hounsfield Unit (HU) parameters for development of a predictive scoring model (TSMAS). No clinical or therapeutic intervention was performed.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years * Diagnosed with tracheal stenosis * Underwent thoracic CT imaging at the time of diagnosis * CT scans available in adequate quality and in DICOM format * No prior surgical treatment for tracheal stenosis before CT imaging

Exclusion criteria

* Tracheal stenosis due to malignancy, foreign body, or tracheobronchial tumors * History of tracheal surgery before CT imaging * Poor quality CT images (e.g., motion artifacts, incomplete tracheal segments) * Patients with a history of radiotherapy (RT) to the neck or mediastinum

Design outcomes

Primary

Measure	Time frame	Description
Prediction of Surgical Requirement Based on Tracheal Diameter on Initial CT	From initial diagnosis to surgical decision (up to 12 months)	Evaluation of whether smaller tracheal diameter on initial CT is associated with need for surgery. Unit of Measure: millimeters
Prediction of Surgical Requirement Based on Tracheal Wall Thickness on Initial CT	From initial diagnosis to surgical decision (up to 12 months)	Evaluation of whether increased tracheal wall thickness on initial CT predicts surgical need. Unit of Measure: millimeters
Prediction of Surgical Requirement Based on HU Values of the Stenotic Segment on CT	From initial diagnosis to surgical decision (up to 12 months)	Evaluation of whether high HU values in the stenotic segment predict surgical need. Unit of Measure: Hounsfield Units (HU)

Contacts

Primary ContactCaner İşevi, MD

drcanerisevi@gmail.com+903623121919

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026