Aneurysm Cerebral
Conditions
Keywords
craniotomy, aneurysm clipping, aspirin, postoperative bleeding
Brief summary
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm. Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots? To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery. The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.
Interventions
OTHERObservation
Observation of intraoperative and postoperative outcomes
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> or = 18 years old * Patients willing to participate and provide an informed consent * Patients undergoing elective craniotomy for cerebral aneurysm clipping * Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not on aspirin therapy for at least 7 days (control group) preoperatively.
Exclusion criteria
* Emergency craniotomy * Use of other antiplatelet or anticoagulant medications within 7 days prior to surgery * Known bleeding disorders (e.g. hemophilia, thrombocytopenia) * History of intracranial hemorrhage unrelated to aneurysm * Inability to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Hemorrhage Rate | 48 hours postoperatively | The incidence of postoperative hemorrhage detected on CT scans within 48 hours after surgery. |
| Intraoperative Blood Loss | From start to end of surgery | Measured by the change in hemoglobin and hematocrit levels from preoperative baseline to immediate postoperative period. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Bleeding Severity | From start to end of surgery | Rated by the operating surgeon using a standardized 5-point Likert scale (0 = no bleeding to 4 = severe bleeding) |
| Need for Blood Transfusion | From start of surgery to day of discharge, up to 7 days | The number of patients requiring intraoperative or postoperative blood transfusions. |
| Length of hospital stay | From end of surgery to day of discharge, up to 7 days | Duration of hospitalization from the day of surgery to discharge |
| Surgical complications | From end of surgery to day of discharge, up to 7 days | Incidence of surgical complications such as infection or reoperation. |
Countries
Italy, Russia, United States
Contacts
Primary ContactShaun Gruenbaum, MD, PhD
Outcome results
None listed