Acute Pancreatic Fluid Collection, Acute Pancreatitis
Conditions
Keywords
acute pancreatis
Brief summary
This observational study aims to evaluate the penetration of intravenously administered antibiotics into pancreatic fluid collections in patients with suspected infected walled-off pancreatic necrosis (WOPN). In selected patients undergoing percutaneous or endoscopic drainage of the collection as part of their clinical care, a small sample of pancreatic fluid will be collected and analyzed to determine the concentration of the administered antibiotic. At the same time, a blood sample will be taken to assess the antibiotic concentration in plasma. By comparing the concentrations in pancreatic fluid and plasma, the study seeks to determine the extent to which different antibiotics (e.g., meropenem or piperacillin-tazobactam) reach the site of infection within the pancreas. All procedures performed as part of the study, with the exception of the antibiotic concentration measurement, are standard components of routine care for patients with complicated acute pancreatitis. Participation in the study does not alter the diagnostic or therapeutic management of the patient. Patients provide written informed consent before enrollment. The results of this study may help optimize antibiotic dosing in patients with infected pancreatic collections and contribute to more effective and individualized treatment strategies in the future.
Interventions
None listed
Sponsors
Brno University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Signed informed consent * Undergoing percutaneous or endoscopic drainage/puncture of a pancreatic fluid collection
Exclusion criteria
\- Failure or refusal to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic concentration ratio between pancreatic fluid and plasma | Within 6 hours after antibiotic administration | Ratio of antibiotic concentration in pancreatic fluid (WOPN) to plasma concentration, determined from simultaneously collected samples after intravenous antibiotic administration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measured concentrations of antibiotics in pancreatic fluid and plasma | Within 6 hours after antibiotic administration | Absolute concentrations of meropenem and piperacillin in pancreatic fluid and plasma from simultaneously collected samples. |
Countries
Czechia
Outcome results
None listed