Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence

Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence: A Randomized Clinical Study

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07084194

Enrollment

Registered

2025-07-24

Start date

2025-09-10

Completion date

2026-08-10

Last updated

2025-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Flare up, Flare Up, Symptom, Postoperative Pain

Keywords

postoperative pain, flare up, nano-technology, irrigation, chitosan, aloe-vera

Brief summary

This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.

Interventions

OTHERChitosan Nanoparticles Irrigant

using Chitosan Nanoparticles irrigant as a final irrigation solution.

OTHERaloe vera nanoparticles irrigant

using Aloe Vera Nanoparticles irrigant as a final irrigation solution.

DEVICEDiode Laser Activation

activation of nanoparticles irrigants using diode laser

DEVICEultrasonic activator

activation of nanoparticles irrigants using ultrasonic activator

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Age 18-60 (adults only) * multiple-rooted with multiple root canal. * Permanent teeth with mature apex and complete root formation. * Without root caries. * Tooth must be restorable. * Without anatomical abnormalities such as fusion. * Healthy patient category I according to ASA. * Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis. * No periapical radiolucency. * Consent Patients for who consent to participate and attend follow-up appointments.

Exclusion criteria

* single root canals or double root. * Root canal calcifications. * Root resorption or fracture. * Previously root canal treated teeth. * immunocompromised patients. * Pregnant females * Patients with systemic diseases as diabetic or hypertension patients. * Patients with facial swelling. * patients who use analgesics or antibiotics within 48-72 hours. * Allergy to any materials used (e.g., irrigants or anesthetics). * psychiatric illness * Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth. * Previously endodontically treated teeth. * Teeth with sinus tract.

Design outcomes

Primary

Measure	Time frame	Description
postoperative pain intensity Postoperative pain is to be assessed using visual analog scale (VAS), A scale from (0 to 10) where 0 means no pain and 10 means a severe pain that has never faced before.	[Time Frame: 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.]	Patients will be contacted by phone at 6, 12, 24, 48, 72 hours and 7 days after the first visit to collect the postoperative pain data.

Secondary

Measure	Time frame	Description
Flare-Up Incidence Flare-up is assessed through asking the patient to notify the investigator if any sudden severe pain or swelling takes place.	[Time Frame: Within 7 days post-treatment)	This could require an unscheduled emergency visit or prescription of additional medication.

Contacts

Primary ContactRabee Ibrahaim Alhabibi

rabieibrahaim@gmail.com+201018836570

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026