ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Conditions
Brief summary
To investigate global and regional changes in lung ventilation and perfusion induced by prone position in ARDS patients assessed by 3D-EIT. And to investigate the difference between 2D-EIT and 3D-EIT in prone position monitoring.
Interventions
BEHAVIORALProne position
Patients were ventilated based on the ARDS-Net recommendations . Patients were kept in a supine position. The process of lung ventilation and perfusion assessment was as follows: 1. PEEP was determined by the attending doctor and was kept the same during the supine and prone period. 2. 3D-EIT was used to monitor the ventilation and perfusion of ARDS patients at three timepoints: T1: supine position, T2: prone position at 30min, T3: prone position over 10 hours.
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients on mechanical ventilation. * Diagnosis of ARDS was based on the Berlin definition * Patients in need of prone position because of clinical condition
Exclusion criteria
* Under 18 years of age. * Pregnant women; * Ribcage malformation * Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional ventilation monitored by EIT | 5-10minutes | Using EIT to monitor the regional ventilation during supine and prone position, to monitor the ventilation distribution change. |
| Regional perfusion monitored by EIT | 5-10minutes | Using EIT to monitor the regional perfusion during supine and prone position, to monitor the ventilation distribution change. |
| V/Q monitored by EIT | 5-10minutes | Ventilation and perfusion monitored by EIT in supine and prone position. To evaluate the V/Q match, deadspace and shunt lung region. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory system compliance | 1 day | Monitor the respiratory system compliance during supine and prone position |
| SpO2 | 1 day | Monitor the SpO2 during supine and prone position |
Countries
China
Contacts
CONTACTHuaiwu He
Outcome results
None listed