Juvenile Idiopathic Arthritis
Conditions
Brief summary
Juvenile Idiopathic Arthritis (JIA) is a prevalent pediatric rheumatic disorder characterized by persistent inflammation of one or more joints in children and adolescents. This chronic condition is a major contributor to both short- and long-term morbidity and functional disability We aim in this study to investigate the role of CAR, PLR, NLR ,systemic inflammatory index (SII ) and NAR ( SII and NAR have never been evaluated before in JIA patients ) as potential markers of disease activity in patients with non-systemic JIA (nsJIA) .
Interventions
DIAGNOSTIC_TESTcomplete blood count
blood test
DIAGNOSTIC_TESTserum albumin
blood test
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
Yes
Inclusion criteria
\- 1\. Patients who classified JIA according to International League of Associations for Rheumatology ILAR criteria on treatment with exclusion of systemic JIA. 2\. Patients with disease duration more than 6 months. 3. Age below 16 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent or their parents/guardians
Exclusion criteria
* 1\. Systemic JIA. 2. Patients with other autoimmune or autoinflammatory diseases, immunodeficiencies, hematologic conditions, malignances and infectious disease at enrollment time or in the previous 2 weeks. Patients who are not able and willing to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| possibility to use crp to albumin level as novel biomarker to predict disease activity in juvenile 0idiopathic arthritis | 6 months |
| possibility to detect systemic inflammatory index and its relation to disease activity and risk of flare in juvenile idiopathic arthritis | 6 months |
| assessment of activity of disease according to JDAS SCORE | 6 months |
| assessment of neutrophils to albumin ratio and its relation to JDAS score activity score | 6 months |
Contacts
Primary ContactHadeer F Mohamed, resident
Backup Contactosama S Daifallah, AssistantProf
Outcome results
None listed