Temporal Interference for Temporal Lobe Epilepsy Under SEEG

Evaluating Biomarkers of Temporal Interference for Temporal Lobe Epilepsy Under SEEG

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07082101

Acronym

TITE-SEEG

Enrollment

Registered

2025-07-24

Start date

2025-08-15

Completion date

2026-08-31

Last updated

2025-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Brief summary

This study evaluates the effect of temporal interference (TI) stimulation on biomarkers in patients with temporal lobe epilepsy (TLE) under stereo-electroencephalography (SEEG), and provides theoretical basis for non-invasive TI treatment of temporal lobe epilepsy.

Detailed description

10 patients aged 18-65 years with TLE assessed by semiology, video electroencephalogram and imaging in Epilepsy Center of Xijing Hospital (Xi'an, China) will be recruited. Clinical baseline data such as general information and history of seizures will be collected. The SEEG electrodes were implanted in the Department of neurosurgery of Xijing Hospital and after 24 hours TI will be performed with continuous SEEG monitoring. Finally, the biomarker changes of EEG signals before and after TI treatment were statistically analyzed.

Interventions

OTHERtemporal interference

In this intervertion, patients with SEEG operation will take temporal interference (TI) stimulation and the deep brain EEG will be monitorated through the entire experiment.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of drug refractory epilepsy and temporal lobe epilepsy; * Patients undergoing SEEG; * Able to cooperate the treatment and related inspection; * Fully understands and signs informed consent.

Exclusion criteria

* Patients with temporal plus epilepsy; * In status epilepticus; * With other severe disease; * Pregnancy or lactation women; * Unable to tolerate SEEG or TI; * At the same time to participate in other clinical trials; * Withdraw consent procedure.

Design outcomes

Primary

Measure	Time frame	Description
Number of interictal electrophysiological biomaker changes in epilepsy	24 hours after TI stimulation	Electrophysiological biomarkers changes recorded by SEEG through the experiment.

Countries

China

Contacts

Primary ContactWen Jiang

jiangwen@fmmu.edu.cn+86-02984773664

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026