New Saline-contrast EIT Method Without Breath Hold by Low Pass Filter

A Novel Saline-contrast EIT Method for Lung Perfusion Estimation: Without Breath Hold by Low Frequency Band Pass Filter

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07081295

Enrollment

Registered

2025-07-23

Start date

2024-09-10

Completion date

2024-10-15

Last updated

2025-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Diseases

Brief summary

The electrical impedance tomography (EIT) is a bedside, non-invasive, non-radiation imaging tool for lung mornitoring. Currently, the EIT saline-contrast method for lung perfusion evaluation has been widely used in clinical. However, this technique requires the patient to hold breath for 8-30s to avoid the respiratory interference. Hence, it is not suitable for patients that can not tolerate breath hold or unable to maintain a steady apnoea. This study aims to develop an algorithm system based on low frequency band pass filter for EIT saline-contrast lung perfusion estimation without ventilation interruption, and investigate the correlation and agreement of EIT results between the novel method and the conventional breath-hold method.

Interventions

OTHERInjection of hypertonic saline

Injection 10 mL of 10% NaCl through central venous catheter

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 79 Years

Healthy volunteers

Inclusion criteria

* In need of lung perfusion assessment due to clinical condition * With central venous catheter

Exclusion criteria

* Pregnant or breastfeeding females * contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.) * severe hyperchloremia (\>155 mmol/L) * unable to tolerate breath-hold maneuver * edema disease (nephrotic syndrome, cirrhotic ascites, congestive heart failure, etc.) * Patients with severe hypernatraemia or hyperchloremia and severe hypertonicity * Hypertension (\>160/100 mmHg), hypokalaemia (\> 3.5 mmol/L) * Acute renal failure in oliguric stage, chronic renal failure with reduced urine output and poor response to diuretics

Design outcomes

Primary

Measure	Time frame
Regional V/Q match	Offline analysis, immediately after the saline injection procedure

Secondary

Measure	Time frame
Pixel-wise lung perfusion fraction	Offline analysis, immediately after the saline injection procedure

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026