Keratoconus
Conditions
Brief summary
This prospective interventional study investigates the efficacy of corneal cross-linking (CXL) in managing progressive keratoconus in pediatric patients. The procedure involved standard epithelium-off CXL, and patients were followed to assess outcomes such as visual acuity, keratometric stability, and corneal thickness.
Interventions
PROCEDURECrosslinking
Corneal Cross-Linking (CXL) is a minimally invasive procedure used to strengthen the cornea by increasing the chemical bonds between collagen fibers. It is primarily used to treat keratoconus and corneal ectasia, conditions where the cornea becomes progressively thinner and weaker.
Sponsors
Al-Azhar University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 20 Years
Healthy volunteers
No
Inclusion criteria
* Age between 8 and 18 years * Clinical and topographic diagnosis of keratoconus based on the Belin/Ambrosio Enhanced Ectasia Display * Evidence of progression within the past 6-12 months (e.g., an increase in maximum keratometry (Kmax) by ≥1.0 diopter, a decrease in minimal corneal thickness by ≥10 µm, or deterioration in visual acuity not attributable to other causes
Exclusion criteria
* Corneal scarring or opacities. * Active ocular infection or inflammation. * Prior ocular surgery or trauma. * Autoimmune or connective tissue disorders.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| keratometry (Kmax) | Baseline | Kmax (Maximum Keratometry) is the steepest point of curvature on the cornea, and it is a key parameter in diagnosing and monitoring keratoconus. |
| BCVA | Baseline | Measurment of the visual acuity |
Countries
Egypt
Outcome results
None listed