Neonatal Hyperbilirubinemia
Conditions
Keywords
newborn, hyperbilirubinemia, phototherapy, bilirubin, transcutaneous bilirubin, serum bilirubin
Brief summary
This study aimed to assess the accuracy of transcutaneous bilirubin measurements in term and late-preterm infants undergoing phototherapy. Transcutaneous bilirubin levels were measured from different anatomical sites during and after treatment, and compared to total serum bilirubin levels. The agreement between the two methods was evaluated using Bland-Altman plots.
Detailed description
This study focused on evaluating the accuracy of transcutaneous bilirubin measurements in term and late-preterm infants who were receiving phototherapy treatment. Transcutaneous bilirubin levels were measured at two different locations - the glabella (forehead) and lower abdomen - while the infants were undergoing phototherapy. These measurements were then compared to total serum bilirubin levels, which is the gold standard for assessing bilirubin levels in the blood. The researchers used Bland-Altman plots to analyze the agreement between the transcutaneous bilirubin measurements and total serum bilirubin levels. By comparing the transcutaneous bilirubin measurements to total serum bilirubin levels using Bland-Altman plots, the researchers were able to determine the accuracy of the transcutaneous measurements in this specific population of infants undergoing phototherapy. This information is important for healthcare providers to ensure that they are using the most accurate and reliable method for monitoring bilirubin levels in infants receiving treatment for jaundice.
Interventions
DIAGNOSTIC_TESTserum bilirubin level measurement
Total serum bilirubin levels and concurrent transcutaneous bilirubin measurements will be done and the results will be evaluated comperatively.
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 2 Weeks
Healthy volunteers
No
Inclusion criteria
* Newborn infants less than 7 days of life * Hyperbilirubinemia requiring phototherapy * Indirect hyperbilirubinemia * Newborn infants who are born between 35-42 weeks of gestation
Exclusion criteria
* Direct hyperbilirubinemia * Disease states other than hyperbilirubinemia * Congenital abnormalities * Chromosomal abnormalities * Poor peripheral perfusion * Edema
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation coefficient of transcutaneous bilirubin (TcB) and total serum bilirubin (TSB) | from enrollment to 24th hour after the end of the phototherapy treatment | The accuracy of TcB as a substitute of TSB will be evaluated through correlation and Bland-Altman analysis |
Countries
Turkey (Türkiye)
Outcome results
None listed