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Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations

Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07080320
Acronym
REGARD
Enrollment
60
Registered
2025-07-23
Start date
2025-09-20
Completion date
2027-09-01
Last updated
2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging, Facial Skin, Motion Capture, Periorbital Region, Skin Movement, Vertical Jump

Keywords

Facial skin, motion capture, aging, periorbital region, mechanical, skin movement, vertical jump

Brief summary

The periorbital region of the face is a critical area affected by aging. Motion Capture (MoCap) allows the precise measurement of the mechanical properties of skin in this region. This study will validate MoCap as a tool for quantifying these properties, comparing it to traditional reference tools, and exploring how these properties evolve with age and external treatments. It will also assess MoCap's ability to detect the effects of various treatments such as tightening products and massages. Ultimately, this research will provide a deeper understanding of skin dynamics in the periorbital region and offer insights into both medical and cosmetic applications.

Interventions

DEVICEMoCap

For each subject, the displacement of markers, the deformation of regions between markers, and the evolution of angles formed by the markers during facial expressions and vertical movements will be analyzed with MoCap. These will be compared between the two age groups (18-33 years vs. 50-65 years) using a MANOVA model. The reference values for marker displacement will be defined by the interval between the 2.5% and 97.5% percentiles of the values for each marker. If the distribution is Gaussian, the percentiles will be derived from the standard normal distribution; otherwise, the non-parametric method will be used. The intervention will be Interventions : * Recruitment of healthy and pathological subjects. * Full-face and macro images of the periorbital region * Measurement of periorbital skin properties using MoCap and standard reference tools. * Application of a tightening product (aloe vera) and periorbital massage. * Measurement of skin response to a vertical jump.

Sponsors

Centre Hospitalier Universitaire, Amiens
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Female participants * Caucasian, Fitzpatrick skin types I-III * BMI between 18.5 and 27, healthy participants * Aged 18 to 65 years (inclusive) * Not under guardianship or curatorship * Informed written consent * Social security affiliation * Non-smokers for at least 5 years * No excessive UV exposure (artificial or natural) in the last 3 weeks prior to the study or during the study

Exclusion criteria

* Severe skin disorders preventing the application of electrodes or photo-reflective markers * Neurovascular history affecting the face * Ongoing treatments influencing facial tissues (e.g., corticosteroids) * Current sleep disorders * Psychiatric conditions or social interaction impairments * Inner ear or balance disorders * Osteoporosis, recent fractures, or fragile bone conditions * Pregnant or breastfeeding women * Under guardianship, curatorship, or legal protection

Design outcomes

Primary

MeasureTime frameDescription
maximum displacement (in millimeters) of each marker placed on the faceday 1maximum displacement (in millimeters) of each marker placed on the face during standardized movements of the periorbital region

Secondary

MeasureTime frameDescription
Coefficient of variation of the maximum displacement amplitudes measured during repeated tests for the same movement.day 1
The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.day 1The correlation coefficient between dynamic MoCap measurements and static measurements obtained from reference tools.
The difference in the mean maximum displacement amplitudes (in millimeters) between different age groupsday 1The difference in the mean maximum displacement amplitudes (in millimeters) between different age groups
The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massageday 1The difference in the mean maximum displacement amplitudes (in millimeters) before and after performing a periorbital massage
The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).day 1The maximum mean displacement amplitudes (in millimeters) during a mechanical solicitation (a standardized vertical jump).
The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).day 1The difference in the mean maximum displacement amplitudes (in millimeters) before and after applying a tightening product (aloe vera).

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026