Effects of Micellar Water Application on Skin Barrier Integrity, Hydration, and Erythema in Healthy Skin
Conditions
Brief summary
The goal of this clinical trial is to assess how micellar water affects the skin barrier in healthy adult volunteers. The main questions it aims to answer are: * Does leaving micellar water on the skin affect skin barrier function differently than rinsing it off? * Are there measurable differences in transepidermal water loss (TEWL), skin hydration, and erythema between the two application methods? Researchers will compare the effects of micellar water left on the skin versus rinsed off after application. Participants will: * Be randomly assigned to one of two groups * Apply micellar water to their forehead once daily for 21 days * Either leave the micellar water on or rinse it off, depending on their group * Undergo non-invasive measurements of TEWL, skin hydration, and erythema before and after the intervention
Interventions
PROCEDUREMicellar Water Application (No Rinse)
Participants apply micellar water to the forehead once daily and leave it on the skin without rinsing for 21 days.
PROCEDUREMicellar Water Application (With Rinse)
Participants apply micellar water to the forehead once daily and rinse it off after application for 21 days.
Sponsors
University of Split, School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adult volunteers aged 18 years and older. Willingness and ability to comply with study procedures. Signed informed consent indicating understanding of study participation, rights, and potential risks and benefits. No current skin diseases or conditions at the test site. Ability to attend all study visits and follow instructions
Exclusion criteria
* Participants with skin diseases, skin cancers, or sun damage at the test site will be excluded. Use of immunomodulators, corticosteroids, or antihistamines within 30 days prior to the study start is exclusionary. Application of emollient creams within 3 days before the trial is not permitted. Other
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in TransEpidermal Water Loss (TEWL) | Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21). | Measurement of transepidermal water loss on the forehead to assess skin barrier function. |
| Change in Skin Hydration | Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21). | Measurement of skin hydration levels on the forehead before and after micellar water application. |
| Change in Erythema | Four measurements total: one at baseline (before application), and one at the start of each week during the 3-week intervention (Days 0, 7, 14, and 21). | Assessment of skin redness (erythema) on the forehead before and after of micellar water application. |
Countries
Croatia
Outcome results
None listed