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Effect of Stellate Ganglion Block on Arterial Catheterization Complications in Selected Group of Patients Undergoing Elective Cardiac Surgeries

Effect of Stellate Ganglion Block on Arterial Catheterization Complications in Selected Group of Patients Undergoing Elective Cardiac Surgeries

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07077824
Acronym
stellate block
Enrollment
40
Registered
2025-07-22
Start date
2025-07-15
Completion date
2026-03-01
Last updated
2025-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery

Keywords

stellate ganglion block, femoral radial gradient, arterial catheterization complications

Brief summary

Radial artery catheterization is the usual method for invasive monitoring in cardiac surgeries. Although it is relatively safe, complications do happen. Hematoma and ischemia are well known complications. Also, radial-to-femoral arterial pressure gradient (RFAPG) post bypass is a common event which affect management of a critical patient in a critical time. the study examines the effect of left stellate ganglion block (LSGB) on decreasing radial artery complications in cardiac surgeries

Detailed description

Invasive blood monitoring is an essential prerequisite in all cardiac surgeries where the radial artery is the most common one used. It is easily accessible, apart from important nerves and has a well-known safe profile. As perfection is an unattainable dream, radial artery complications do happen ranging from spasm, occlusion, hematoma formation and dissection Although incidence of ischemia post radial artery occlusion is not as common as the occlusion, serious effects do happen as reported digital necrosis and the need to do below elbow amputation in one case Patients undergoing cardiac surgeries usually suffers from many risk factors for Ischemic complications as risk of hypotension and use of vasoconstrictors The use of vasoconstrictors is more expected in patients with preoperative decreased Left Ventricle (LV) function (≤30%), moderate to severe Pulmonary Hypertension (PH), multiple procedures and prolonged bypass time. Also, a complication that is relatively common in open heart surgeries is the central to radial artery pressure gradient that is usually encountered post bypass and may last for some time after and may affect up to 45% of patients in cardiac surgeries. Usually the pressure gradient is for favor of the radial artery in awake patients due to the vascular resistance, but many theories tried to explain the cause of the opposed gradient post bypass. One theory related the issue to Vasoconstriction of the brachial artery. Over the last few years, there were some studies, which investigated the effect of regional anesthesia techniques such as thoracic epidural anesthesia (TEA) and stellate ganglion block (SGB) for sympatholysis in cardiac surgeries The SGB with local anesthetics have been widely used to provide pain relief to treat vascular spastic disorders of upper limbs, chronic pain conditions and treatment of refractory angina The SGB has also been used for increasing radial artery (RA) blood flow and preventing RA spasm by sympathetic blockade in coronary artery bypass surgery In the current study, SGB will be studied regarding its effect in minimizing the occurrence of complications related to arterial catheterization in selected patients in cardiac surgeries.

Interventions

Patients will receive left stellate ganglion block US guided after induction of anesthesia and intubation and after insertion of Rt IJV CVL and before skin incision

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* • Multiple procedures with expected prolonged bypass time (\>100 min) * EF\< 35% * Moderate or severe Pulmonary hypertension

Exclusion criteria

* • Patient not willing to participate in the study. * History of strokes / Transient ischaemic attacks * History of Glaucoma. * History of allergy to local anaesthetic drugs. * Pre-existing contralateral phrenic nerve palsy. * Patients with existing coagulopathy. * BMI \>35

Design outcomes

Primary

MeasureTime frameDescription
Incidence of arterial ischemiafrom end of surgery till hospital discharge aproximately one weekIncidence of arterial ischemia in form of colour changes and confirmed by arterial duplex

Secondary

MeasureTime frameDescription
• Incidence of radial to femoral artery pressure gradientfrom weaning from cardiopulmonary bypass till transferal to icu aproximately 1-2 hours• Incidence of radial to femoral artery pressure gradient which is defined as one of the following: \>25 mmhg in systolic BP or \> 10 mmhg in mean BP that is sustained for \> 5 minutes either before, on or after CPB

Countries

Egypt

Contacts

Primary Contactabdallah M soudi
Dr.soudi2014@med.asu.edu.eg+201111228925

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026