High-Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

Comparative Assessment of High Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07076745

Enrollment

Registered

2025-07-22

Start date

2025-01-01

Completion date

2025-07-10

Last updated

2025-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Stiffness, Coronary Slow Flow, High-sensitivity C-reactive Protein

Brief summary

This study aims to compare the levels of high-sensitivity C-reactive protein (hs-CRP) and carotid artery stiffness between patients with coronary slow flow phenomenon (CSFP) and those with normal coronary flow.

Detailed description

The coronary slow flow phenomenon (CSFP) is characterized by delayed opacification of the coronary arteries during angiography in the absence of significant epicardial coronary artery disease. Hypothesis: High-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and has been associated with various cardiovascular conditions. Elevated hs-CRP levels have been observed in patients with CSFP, suggesting an inflammatory component in its pathogenesis. This marker not only predicts future cardiovascular events but may also reflect ongoing vascular inflammation in patients with angiographically normal coronary arteries.

Interventions

DIAGNOSTIC_TESTHigh-sensitivity C-reactive protein

High-sensitivity C-reactive protein will be done.

OTHERStiffness Measurement

Measurements will include carotid intima-media thickness (CIMT), systolic (Ds) and diastolic (Dd) diameters, and calculation of stiffness indices: * β-stiffness index. * Peterson's elastic modulus (Ep). * Distensibility coefficient (DC). * Compliance coefficient (CC). * Strain.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥18 years old. * Both sexes. * Patients undergo coronary angiography for evaluation of chest pain or suspected ischemia.

Exclusion criteria

* Pregnant or breastfeeding women. * History of cardiovascular events such as myocardial infarction or stroke. * Diagnosed autoimmune disorders, chronic hepatic or renal diseases. * Current or recent infections. * History of malignancy. * Patients taking medications known to affect inflammatory markers (e.g., corticosteroids or immunosuppressants).

Design outcomes

Primary

Measure	Time frame	Description
High Sensitive C-reactive protein	24 hours post-angiography	High Sensitive C-reactive protein will be measured.

Secondary

Measure	Time frame	Description
Stiffness indices	24 hours post-angiography	Stiffness indices will be measured.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026