Spinal Hypotension, Caffeine
Conditions
Keywords
Spinal hypotension, Caffeine, Cesarean delivery
Brief summary
Hypotension after spinal anesthesia is critical. Thus several interventions have been proposed to mitigate such effect.
Detailed description
Hypotension is a critical issue related to spinal anesthesia during cesarean delivery. Researchers of this study aimed to evaluate the impact of preoperative oral caffeine on the incidence of spinal hypotension during cesarean delivery.
Interventions
Oral caffeine will be given as 200 mg before spinal anesthesia
DRUGPlacebo
Patient at this arm will receive placebo
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* full term pregnant * undergoing elective cesarean delivery
Exclusion criteria
* patient refusal * baseline systolic pressure \< 100 mmHg * contraindication to spinal anesthesia * allergy to caffeine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of spinal hypotension | After spinal anesthesia till delivery | Decrease systolic blood pressure \< 20% of baseline value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to first hypotensive episode | after induction of spinal anesthesia | time to incidence of hypotension |
| Incidence of severe hypotension | After onset of spinal anesthesia | reduced systolic pressure \< 60% of baseline value |
| APGAR score | at 5 minutes after delivery | APGAR score calculation at 5 minutes |
| Umbilical artery pH | At 5 minutes after delivery | Umbilical artery blood gases |
Countries
Egypt
Outcome results
None listed