Antimicrobial Locks for Hemodialysis Catheter Infections

Effect of Tunneled Hemodialysis Catheter Antimicrobial Lock Solution in Prevention of Catheter Related Blood Stream Infection.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07074821

Enrollment

100

Registered

2025-07-20

Start date

2023-03-01

Completion date

2024-07-24

Last updated

2025-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter Related Blood Stream Infection, Hemodialysis, Vascular Access

Keywords

catheter related infection, hemodialysis, Taurolidine

Brief summary

Tunneled hemodialysis catheters are susceptible to infection with high incidence of complication to the hemodialysis patients .The study aimed to prevent catheter infection through comparing use of antimicrobial solution (Taurolidine) when used as lock solution installed in the lumen of the catheter at the end of the hemodialysis session with the usually used lock solution heparin. The Study was performed on 100 hemodialysis patients over one year in Sohar hospital ,Oman .

Interventions

DRUGTaurolidine citrate 4% and heparin 500

Taurolidine ,citrate 4% and heparin 500 units per ml used as lock solution in tunneled hemodialysis catheter

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

13 Years to No maximum

Healthy volunteers

Inclusion criteria

\- All clinically stable adult end stage renal disease patients commence regular hemodialysis through tunneled hemodialysis catheter at Sohar hospital hemodialysis unit.

Exclusion criteria

* Patients with difficult vascular access and the tunneled hemodialysis catheter is the only functioning vascular access . * Patients with poor flow from the catheter. * Patients with active infection . * Patients have displayed allergic reactions to either citrate or taurolidine. * Patients were taking medication incompatible with either citrate or taurolidine

Design outcomes

Primary

Measure	Time frame	Description
Comparison between both groups in terms of incidence of Catheter related blood stream infection	one year	The investigators have studied the incidence of catheter related bacterial infection in both groups to determine superior effectiveness of Taurolidine lock solution than Heparin lock only in terms of prevention of infection .

Secondary

Measure	Time frame	Description
Comparison between both groups in terms of treatment cost	one year	The secondary outcome measure was to compare the treatment cost in both groups to determine cost effectiveness

Countries

Oman

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026