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CT and Endoscopic Biopsy Image-Based Deep Learning for Predicting Left Recurrent Laryngeal Nerve Lymph Node Metastasis in Esophageal Cancer

CT and Endoscopic Biopsy Image-Based Deep Learning for Predicting Left Recurrent Laryngeal Nerve Lymph Node Metastasis in Esophageal Cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07074535
Enrollment
500
Registered
2025-07-20
Start date
2019-01-01
Completion date
2027-12-30
Last updated
2025-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Learning, Esophageal Squamous Cell Cancer (SCC), Postoperative Complication, Recurrent Laryngeal Nerve Palsy

Brief summary

The goal of this observational study is to develop a predictive model for left recurrent laryngeal nerve (RLN) lymph node metastasis using deep learning algorithms. The model will be developed using clinical data from previous esophageal cancer surgeries, including preoperative CT imaging, and histopathological images from gastroscopic biopsies. The model will also be validated through prospective clinical trials to guide the intraoperative lymph node dissection, thereby reducing postoperative risks of RLN injury.

Interventions

None listed

Sponsors

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Preoperative gastroscopic biopsy confirmed esophageal squamous cell carcinoma; * The patient underwent esophagectomy with lymph nodes dissection along the left recurrent laryngeal nerve.

Exclusion criteria

* The patient's medical records are incomplete; * The patient refused to participate in the trial.

Design outcomes

Primary

MeasureTime frameDescription
AUROC (Area Under the Receiver Operating Characteristic Curve)From enrollment to the end of treatment at 4 weeksThe discriminant ability of the comprehensive evaluation model at different thresholds (positive vs. negative)

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026