Transvaginal Ultrasound Assessment of Caesarean Section Uterine Scar Closed by Single Versus Double Layer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07074522

Enrollment

Registered

2025-07-20

Start date

2023-12-01

Completion date

2024-11-01

Last updated

2025-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caesarean Section, Double Layer, Single Layer, Transvaginal Ultrasound, Uterine Scar

Brief summary

This study aimed to evaluate uterine scar thickness and integrity using transvaginal ultrasonography in women randomly assigned to single versus double-layer closure of the uterine incision, with a comparison between the two groups.

Detailed description

Cesarean section (CS) is one of the most commonly performed major abdominal operations in women in both high and low-income countries. Single-layer closure using a running locking stitch is associated with decreased operative time and fewer additional haemostasis sutures. An extensive Canadian study found a fourfold increase in the risk of uterine rupture in a woman who had a single layer in their previous pregnancy. Transvaginal ultrasound is a validated tool for evaluating uterine scar defects, commonly referred to as a niche. It is used to asses the uterine scar thickness in a women with previous cesarean delivery.

Interventions

PROCEDURESingle-layer closure

Patients who underwent single-layer closure of the transverse lower segment during cesarean section.

PROCEDUREDouble-layer closure

Patients who underwent double-layer closure of the transverse lower segment during cesarean section.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Age from 20 to 40 years old. * Pregnant women underwent their first cesarean section.

Exclusion criteria

* Body mass index (BMI) ≥ 30 kg /m2. * Multiple gestations. * Uterine malformation. * Placenta previa. * Placenta accreta. * Uterine or cervical fibroid. * Any previous uterine operation or any medical disease that compromises wound healing, such as diabetes mellitus, collagen diseases, anemia, or corticosteroid therapy.

Design outcomes

Primary

Measure	Time frame	Description
Uterine scar thickness	6 months postoperatively	Uterine scar thickness was evaluated by transvaginal ultrasound six weeks, three months, and six months postoperative.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026