Aerobic Exercise Phoenix Seed, Antioxidant Potential
Conditions
Brief summary
the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions
Detailed description
reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases. Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system. Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process. Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences. this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.
Interventions
OTHERaerobic exercise
the exercise protocol was applied following these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.
DIETARY_SUPPLEMENTphoenix seed
consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day
COMBINATION_PRODUCTaerobic exercise+ phoenix seed
a specialized programme of aerobic exercise.the exercise protocol follow these characteristics * frequency: 3-5 times /week along the whole study period * intensity: 70% of the maximal heart rate (220- age x 70/100) * duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training. the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day)
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
sedentary obese female aged 35-55 years old with BMI of 30-39.9 and some symptoms of systemic inflammation (˃75 score at the inflammatory questionnaire) and had none of the
Exclusion criteria
could be included in this study. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TAC or total antioxidant capacity (blood test) | test applied before and after 2 months of the intervention protocol | TAC: Determines the total antioxidant capacity of biological samples as a valuable approach to measuring health status under oxidative stress conditions, |
| SOD (superoxide dismutase) | Pre- intervention and after 8 weeks of treatment | a blood test to determine the amount of SOD in blood and giving a good idea of the overall superoxide detoxifying capacity of a cell or tissue |
| MDA (malondialdehyde) | Pre- intervention and after 8 weeks of treatment | blood test that measures Malondialdehyde (MDA) level as a marker of oxidative stress and a contributor to all major diseases by determining the impact of oxidation in normal and cancer cells. |
Contacts
Primary ContactZainab Saeed Aly, lecturer at Horus university
Backup Contactnagwa ammar, professor of pharmacognosy
Outcome results
None listed