Knee Osteoarthristis
Conditions
Brief summary
This study aims to investigate if an integrated approach combining Traditional Chinese and Western medicine can better treat knee osteoarthritis. The goal is to see if this combined therapy can more effectively reduce pain severity and frequency, leading to an improved quality of life for KOA patients. Additionally, the study will explore the underlying mechanisms of pain and anti-inflammation related to KOA.
Interventions
DRUGWestern Medicine
Western medicine treatment only
PROCEDUREherbal medicine and acupuncture
Western medicine combined acupuncture and herbal medicine treatemnt
DRUGherbal medicine
Western medicine combined herbal medicine
PROCEDUREacupuncture
western medicine combined acupuncture
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female aged above 18 years old * Kellgren-lawrence grading scale ≥ II * Numerical rating scale (NRS) ≥ 4
Exclusion criteria
* History of bone tumor * Pregnancy * History of bilateral knee replacement * Active infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| WOMAC | From enrollment to 3 months after treatment completion. | Western Ontario and McMaster Universities Osteoarthritis (WOMAC) subscale |
| NRS | From enrollment to 3 months after treatment completion. | Numerical rating scale (NRS) score for pain |
| Lequesne's index | From enrollment to 3 months after treatment completion. | Lequesne's index |
Outcome results
None listed