Effect of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity

Impact of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity: Nationwide Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07071545

Acronym

PA-NormalWtDM

Enrollment

249247

Registered

2025-07-17

Start date

2010-01-01

Completion date

2023-09-30

Last updated

2025-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes (DM), Physical Activity

Keywords

abdominal obesity, physical activity, Diabetes mellitus

Brief summary

Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using data from the Korean National Health Insurance Service (K-NHIS) database to evaluate the impact of regular physical activity.

Detailed description

It is well established that patients with T2DM and abdominal obesity have worse clinical outcomes. This holds true even among individuals with a normal body weight but central (abdominal) obesity. In this study, the investigators aimed to determine whether engaging in regular physical activity (defined as vigorous exercise at least three times per week) is associated with improved clinical outcomes in normal-weight individuals with abdominal obesity. Specifically, we compared the incidence of MACCE between normal-weight patients with type 2 diabetes who had abdominal obesity and those who did not.

Interventions

BEHAVIORALRegular physical activity

Moderate-to-vigorous physical activity at least three times per week.

BEHAVIORALNo regular physical activity

The group that did not engage in physical activity according to the guidelines

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

\- Patients who were newly diagnosed with T2DM and had a normal body weight at the time of diagnosis.

Exclusion criteria

* Patients with any pre-existing diabetes-related complications * Patients who were overweight or obese based on BMI criteria

Design outcomes

Primary

Measure	Time frame	Description
Major adverse cardiac and cerevrovascular events (MACCE)	10 years after diagnosed T2DM	Composite of all-cause death, myocardial infarction, ischemic stroke, heart failure

Secondary

Measure	Time frame	Description
All cause death	10 years after diagnosed T2DM	Death from all cause
myocardial infarction	10 years after diagnosed T2DM	MI with hospitalization
Ischemic stroke	10 years after diagnosed T2DM	Ischemic stroke after diagnosed T2DM
Heart failure	10 years after diagnosed T2DM	HF with hospitalization

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026