Pain Control After Open Radical Nephrectomy: Thoracic Paravertebral Block Versus External Oblique Intercostal Block

Ultrasound-Guided Thoracic Paravertebral Block Versus External Oblique Intercostal Block for Postoperative Analgesia After Open Radical Nephrectomy: A Randomised Controlled Trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07071012

Enrollment

Registered

2025-07-17

Start date

2025-08-01

Completion date

2026-02-02

Last updated

2026-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

External Oblique Intercostal Block, Nephrectomy, Pain Scores, Paravertebral Block

Keywords

postoperative pain, nephrectomy, External oblique intercostal block, paravertebral block

Brief summary

This study aims to compare the effects of external oblique intercostal block versus paravertebral block on postoperative pain and complications in patients undergoing open nephrectomy.

Interventions

DRUGBupivacaine

Used for regional anesthesia during nephrectomy procedure (e.g., paravertebral or external oblique intercostal block)

DRUGmorphine

Used for postoperative pain control via PCA device

DRUGparacetamol

Used as part of postoperative multimodal analgesia

DRUGDiclofenac

Used as part of postoperative multimodal analgesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Aged 18 to 90 years * Scheduled for elective open radical nephrectomy for renal cell carcinoma * ASA classification I-III * Mini-Mental State Examination score ≥24 * Provided written informed consent

Exclusion criteria

* Neuropathy * Hepatic failure * Coagulopathy * Local anesthetic allergy * Mini-Mental State Examination score \<24 * Refusal to participate

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Pain Score	Up to 24 hours after surgery	Pain intensity measured using Visual Analog Scale at rest. (Visual Analog Scale ranging from 0 = no pain to 10 = worst pain imaginable; higher scores indicate worse pain).

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026