Skip to content

Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07070453
Acronym
PerioFPS
Enrollment
20
Registered
2025-07-17
Start date
2025-04-08
Completion date
2025-11-30
Last updated
2025-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

periodontitis; antimicrobial photodinamic therapy

Brief summary

Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.

Interventions

PROCEDURENon-surgical periodontal treatment

Removal of deposits above and below the gum line using hand or ultrasonic tools and thorough smoothing of root surfaces to discourage re-accumulation of bacteria.

PROCEDUREScaling and root planing + aPDT

Non-invasive treatment that uses a combination of a light-sensitive compound (photosensitizer), specific light, and oxygen to generate reactive oxygen species (ROS) that kill bacteria.

Sponsors

Egas Moniz - Cooperativa de Ensino Superior, CRL
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria and with at least 10 teeth in the mouth.

Exclusion criteria

* Periodontal treatment in the previous six months; use of antibiotics, NSAIDs or immunosuppressants in the previous six months; acute oral infection; pregnant or breastfeeding women; teeth with grade III mobility; pockets with PD \> 10 mm; use of antimicrobial mouthwash in the previous two months; patients with diabetes mellitus.

Design outcomes

Primary

MeasureTime frameDescription
Microbiology outcomeFrom enrollment to the end of treatment at 3 months.Changes in the microbiome collected from periodontal pockets sequencing 16S ribosomal RNA gene

Secondary

MeasureTime frameDescription
Clinical outcomeFrom enrollment to the end of treatment at 3 months.Probing depth, measuring in millimeters the distance from the gingival margin to the base of a sulcus or periodontal pocket, using a periodontal probe.

Countries

Portugal

Contacts

Primary ContactFilipa Sousa, Master
filipampsousa@gmail.com00351 915028912
Backup ContactInês Dra. Gomes, phd
inesgomes.ciiem@egasmoniz.edu.pt00351 212 946 748

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026