Adverse Childhood Experience, Anxiety Symptoms, Cytokine Levels, Depression Symptoms, Immunity, Mindfulness, Positive Thinking, Problem Solving, Psychological Adaptation, Psychological Distress, Resilience, Self-control, Sense of Coherence, Sense of Control, Socio-economic Status, Stress, Stress Response
Conditions
Keywords
psychological immunity, biological immunity, psychoneuroimmunology
Brief summary
This study aims to investigate the links between psychological and biological immunity from the perspective of psychology, epidemiology, and immunology in a general population study sample as well as in a specific group of people in treatment for alcohol addiction.
Detailed description
The study will explore the associations between the level of psychological immunity and the current psychological state of the participants, possible links between the level of psychological immunity in adulthood and adverse childhood experiences, and finally, the association between the psychological immunity and biological immunity expressed by the self- assessed perceived immune status and on a molecular level by quantity of cytokines and in a specific subgroup also by natural killer cells. All this will be studied in a sample of general population as well as in a specific group of people in treatment for alcohol addiction that was chosen based on the known adverse immune-related health effects of excessive alcohol consumption.
Interventions
None listed
Sponsors
Comenius University
Slovak Academy of Sciences
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
for 'General Slovak Population Sample': * Age between 18 - 50 years * Residency in the respective region for at least five years * Consent to participate in the study
Exclusion criteria
for 'General Slovak Population Sample': * Individuals younger than 18 or older than 50 years * Ongoing acute infectious disease on the day of testing * Eligible individuals who do not provide informed consent Inclusion Criteria for the sample 'Individuals receiving inpatient treatment for alcohol addiction at the treatment facility': * Age between 18 - 50 years * Admission to treatment for alcohol addiction * Consent to participate in the study, Treatment completion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The primary outcome measure is the correlation between psychological immunity, current health status and cytokine levels as indicators of biological immune function. | At the time of study enrollment for Group 1, at the time of admission in treatment and after completion of 3 months of treatment for Group 2 | The psychological instrument will consist of the Psychological immune competence inventory (PICI) to assess the psychological immunity. Current health status will be assessed by the epidemiological instrument that will evaluate self-assessed immune status, overall, mental, and physical health, current long-term conditions, social, and economic status. Units of measure for the questionnaires is a score. Cytokine secretion by immune cells will be tested using Bio-Plex ProTM Human Cytokine 17- plex assay according to the instructions of the manufacturer. For the analysis the blood plasma will be used. In each sample the following panel of cytokines will be analysed: G- CSF, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17A, MCP-1 (MCAF), MIP-1β, TNF-α. Cytokine units of measure are picograms per milliliter. |
Countries
Slovakia
Contacts
PRINCIPAL_INVESTIGATORAlexandra Bražinová, prof., MD, PhD
Comenius University, Faculty of Medicine in Bratislava
Outcome results
None listed