Acute Stress Reaction, Cannabidiol, CBD, Stress
Conditions
Keywords
cardiovascular reactivity, , , ,, hypothalamic-pituitary-adrenal axis, stress, mood, CBD use
Brief summary
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
Interventions
OTHERStress Intervention
Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.
Sponsors
University of Minnesota
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Single group assignment; all participants experience baseline rest, acute stress tasks, and recovery rest.
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults who are relatively healthy and aged 21-70 years. * Must keep a normal sleep schedule (sleep during nighttime, awake during daytime). * Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
Exclusion criteria
* Participated in previous acute stress studies that included a similar stress induction. * Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100). * Self-reported current pregnancy. * Self-reported current use of illicit substances (other than cannabis). * Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.) * Students of the principal researcher
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in subjective states (stress, anxiety, positive affect) | 2.5 hours | Participants will self-report the extent to which they have felt stressed, overwhelmed, anxious/nervous, cheerful, and happy during the last 30 minutes before acute stress, immediately after acute stress, and after a recovery period. The Subjective States Questionnaire will be used to score responses. The minimum values are 0 (not at all) and the maximum values are 7 (very strongly). Higher scores mean more stress, more anxiety, and more positive affect. |
| Change in cardiovascular activity and cortisol | 2.5 hours | Saliva will be collected (for later cortisol assays) and cardiovascular activity will be measured before, during, and after acute stress. |
Countries
United States
Contacts
CONTACTStress and Resilience Research Labs
PRINCIPAL_INVESTIGATORMustafa al'Absi
University of Minnesota
Outcome results
None listed