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Greater Occipital Nerve Block Alone Versus Dual Nerve Block in Cervicogenic Headache and Occipital Neuralgia

A Prospective Randomized Study Comparing Greater Occipital Nerve Block Alone Versus Dual Nerve Blockade in the Management of Cervicogenic Headache and Occipital Neuralgia

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07068451
Enrollment
160
Registered
2025-07-16
Start date
2020-01-01
Completion date
2023-04-01
Last updated
2025-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ervicogenic Headache (CEH), Occipital Neuralgia (ON)

Brief summary

This study looked at two types of nerve block injections used to treat people with cervicogenic headache (CEH) and occipital neuralgia (ON)-two painful conditions that often cause pain at the back of the head and neck. The injections target nerves in the upper neck that may be causing the pain. The researchers compared: One nerve injection (greater occipital nerve block, or GONB), versus Two nerve injections (GONB plus lesser occipital nerve block, or LONB).

Interventions

A landmark-guided injection of 1 mL of 2% lidocaine administered at the anatomical location of the greater occipital nerve (GON) to treat cervicogenic headache and occipital neuralgia. Performed without corticosteroids or imaging guidance.

PROCEDURECombined Greater and Lesser Occipital Nerve Block (GONB + LONB)

Two landmark-guided injections of 1 mL of 2% lidocaine each at the anatomical locations of the greater and lesser occipital nerves. Performed without corticosteroids or imaging, targeting broader nerve involvement in cervicogenic headache and occipital neuralgia.

Sponsors

Tishreen University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Adults aged 18 to 65 years Clinical diagnosis of cervicogenic headache (CEH) and/or occipital neuralgia (ON) according to ICHD-3 criteria Pain duration of more than 3 months Pain localized to the occipital region, consistent with the distribution of the greater and/or lesser occipital nerves Inadequate response to conservative therapy (e.g., analgesics, physiotherapy) Willingness to participate and provide written informed consent

Exclusion criteria

Previous nerve block or other interventional procedures for headache Use of systemic corticosteroids within the past 3 months Known allergy to lidocaine or other amide-type local anesthetics Evidence of secondary causes of headache on imaging (e.g., tumor, infection) Pregnancy or breastfeeding Active infection at the injection site Coagulopathy or use of anticoagulant therapy Significant psychiatric or neurological comorbidities interfering with study participation

Design outcomes

Primary

MeasureTime frameDescription
Change in pain intensity measured by the Visual Analog Scale (VAS)Baseline, 24 hours, 3 weeks, and 3 months post-interventionain intensity was assessed using a 10-point Visual Analog Scale (VAS), with 0 indicating no pain and 10 indicating the worst pain imaginable. VAS scores were recorded at baseline and follow-up visits.

Countries

Syria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026