Antibiotic Prophylaxis, CSF Shunts, Hydrocephaly
Conditions
Keywords
Antibiotic prophylaxis, CSF shunts, Hydrocephaly
Brief summary
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections. The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
Interventions
OTHERCefazolin antibiotic prophylaxis
Determination of cerebrospinal fluid concentration
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age \>18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.
Exclusion criteria
* Age \<18 years old * Pregnant women * Infected patients * Known cefazolin allergy * Other molecule used for the antibiotic prophylaxis * Guardianship or conservatorship * Patients under curative antibiotherapy * Non sterile pre operative CSF * Refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cefazolin concentration in the cerebrospinal fluid | The measure is made when the dura mater is opened just before the valve implantation. | Cefazolin concentration in the cerebrospinal fluid. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood cefazolin concentration | Blood samples are made before injection | Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences. |
Countries
France
Contacts
CONTACTBaptiste BOUCHIER, MD
Outcome results
None listed