Ocular Graft Versus Host Disease
Conditions
Brief summary
A case series of patients presented with graft versus host disease with ocular involvement . The study recruited a total of 3 patients who were referred to cornea clinic of Farwaniya Hospital, Kuwait between April 2022 and April 2024. All cases presented with severe dryness, spks and corneal epithelial defect not responding to other measures of treatment. An OmniLenz was applied for each patient for one week. Primary outcome measures included healing of the corneal resistant epithelial defect, secondary outcome measures were improvement of signs of dryness.
Interventions
DEVICEomniLenz
sutureless dehydrated amniotic membrane (omnigen) mounted on contact lens (omnilenz)
Sponsors
Farwaniya Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Ocular graft versus host disease
Exclusion criteria
\- Patient with conjunctival fibrosis and symblephara formation (which interfere with application of the omnilenz)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epithelial healing, Slit lamp examination with cobalt blue light after installation of fluorescein eye drops | 1 week ( duration of the application of omnilenz ) |
Secondary
| Measure | Time frame |
|---|---|
| Omnigen tolerability, Questionnaire for the patients asking about discomfort sensation or the need to patch the eye | 1 week ( duration of the application of omnilenz ) |
Countries
Kuwait
Outcome results
None listed