Thyroid Cancer, Papillary
Conditions
Keywords
central lymph node metastasis, intraoperative pathological evaluation
Brief summary
Efficacy of Intraoperative pathologic evaluation of central lymph nodes
Detailed description
This study aimed to evaluate the effectiveness of intraoperative pathological examination and determine the risk factors for central lymph node metastasis in patients with unilateral clinically node-negative (cN0) papillary thyroid carcinoma.
Interventions
PROCEDUREcentral node dissection
dissection of level VI compartment by AAHNS (American association of head and neck surgeons) classification
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with unilateral papillary thyroid cancer * no evidence of lymph node metastasis (clinically N0) * performed with Intraoperative pathologic evaluation
Exclusion criteria
* those with a history of neck surgery * those with lateral lymph node metastasis * those with suspected extrathyroidal extension * those in whom Intraoperative pathologic evaluation was not performed
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the accuracy of IOPE | Perioperative | To evaluate IOPE accuracy, the findings were compared with the final pathology results, utilizing key parameters such as sensitivity, specificity, false-negative rate (FNR), and false-positive rate for analysis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of complications in IOPE [safety of IOPE] | up to 6 months | The safety was evaluated by examining the incidence of complications, including vocal cord palsy and hypoparathyroidism. vocal cord palsy : measured by laryngeal sono hypoparathyroidism : serum parathyroid hormone levels \< 15.0 pg/mL |
| the risk factors for central lymph node metastasis | perioperative | To determine the risk factors for central lymph node metastasis, univariate and multivariate logistic regression analyses were performed to identify the correlations between clinicopathological characteristics and the final pathological presence of central lymph node metastasis. clinicopathological factors : sex, age (\<55, ≥55), sonographic features, size (\<1cm, ≥1cm) presence of central lymph node metastasis was confirmed by final pathology |
Countries
South Korea
Outcome results
None listed