Renal Transplant, Transplant Complication, Wound Complication
Conditions
Keywords
transplant complication, renal transplant, wound complication
Brief summary
This is a prospective study involving patients undergoing open renal transplant. Renal transplant recipients were randomly divided into two groups: the NPWT group, which received NPWT, and the Standard group, which received standard wound dressings.
Detailed description
This is a prospective study involving patients undergoing open renal transplant between January 2023 and August 2024. Pediatric patients, those requiring surgical reinterventions within the first 3 postoperative months, and patients allergic to NPWT components were excluded from the study. Renal transplant recipients were randomly divided into two groups: the NPWT group, which received NPWT, and the Standard group, which received standard wound dressings. NPWT (PICO by Smith & Nephew) was applied intraoperatively at 80 mmHg and maintained for 7 days. Wound evaluations were performed at 7, 14, 30, and 90 days post-operatively. If dehiscence was present, it was classified as either deep or superficial based on the involvement of the aponeurosis. Patients were assessed for wound infection using the ASEPSIS score, pain with a visual analogue scale, and quality of life using the EQ-5D questionnaire. Scar healing was also evaluated at 30 and 90 days post-operatively with the POSAS score
Interventions
DEVICENWPT group
Patients submitted to negative pressure wound therapy
Sponsors
Universidade do Porto
Centro Hospitalar De São João, E.P.E.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients submitted to kidney transplant
Exclusion criteria
* Pediatric patients, those requiring surgical reinterventions within the first 90 days postoperative, patients allergic to NPWT components, orthotopic transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wound dehiscence | First 90 days after surgery | Wound dehiscence - superficial or deep |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wound infection | First 90 days after surgery | ASEPSIS score - (Additional treatment, Serous discharge, Erythema, Purulen exudates, Separation of deep tissues, Isolation of bacteria, Stay in hospital score); 0-10 points; higher score = worse outcome |
| Pain associated with incision | First 90 days after surgery | Visual analogue scale; score 0-10; higher score=worse outcome |
| Quality of life associated with incision | First 90 days after surgery | EQ-5D questionnaire (The 5-level quality of life version 5); score 0 -100 ; highest score=better outcome |
| Scar healing | First 90 days after surgery | POSAS score (The Patient and Observer Scar Assessment Scale); score 1-10; highest score=worse outcome |
Countries
Portugal
Contacts
Primary ContactAlberto Silva, MD
Outcome results
None listed