BPH (Benign Prostatic Hyperplasia)
Conditions
Keywords
Aloe Vera, Benign prostate hyperplasia, VEGF, Prostate, dutasteride, uroflowmetry, prostatic hyperplasia
Brief summary
This study is a double blinded RCT with pre-post test design on the effect of combination of dutasteride and aloe vera, compared to dutasteride only, on uroflowmetry results, prostate volume, and VEGF serum level among patients with benign prostate hyperplasia. The treatment was given for 12 weeks
Interventions
DRUGAloevera + dutasteride
Dutasteride 0,5 mg/day + Aloe Vera Extract 380 mg/day
Control
Sponsors
Universitas Diponegoro
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosed with BPH clinically or radiologically (prostate volume \> 30 gram, Qmax \<15 mL/s) * Willing to participate to the study
Exclusion criteria
* Clinically or radiologically suspected of having prostatic cancer * Previous prostatic surgery * Patients with urinary retention * Patients with BPH complications: urinary tract infections, urolithiasis, or hydroneprhosis * Previously consumed alpha blocker or 5ARI in the last 6 months * Have consumed aloe vera extract routinely
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Uroflowmetry result | 12 weeks | Qmax of Uroflowmetry result |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prostatic volume | 12 weeks | Measured by transabdominal ultrasonography |
| VEGF | 12 weeks | serum VEGF level |
Countries
Indonesia
Contacts
Primary ContactAchmad Rizky Herda Pratama dr. Achmad Rizky Herda Pratama, Sp.U, S.H, Urologist
Outcome results
None listed