High-flow Anesthesia, Low-flow Anesthesia, Myringoplasty, Neutrophil-to-Lymphocyte Ratio, Tympanoplasty
Conditions
Keywords
Anesthesia high-flow, Anesthesia low-flow, Neutrophil-lymphocyte ratio, Systemic inflammatory response
Brief summary
This retrospective study aims to compare the effects of low-flow and high-flow anesthesia techniques on intraoperative hemodynamics, neutrophil-to-lymphocyte ratio (NLR), and postoperative outcomes in patients undergoing tympanoplasty or myringoplasty. The data were collected from medical records of patients who underwent ear surgery between \[September 1, 2022\] and \[April 1, 2023\]. The study seeks to evaluate whether the choice of anesthetic flow rate has a significant impact on inflammatory response and recovery.
Detailed description
This study investigates the influence of anesthetic gas flow rates on systemic inflammation and hemodynamic stability in middle ear surgeries. While low-flow anesthesia is associated with reduced environmental exposure and cost-effectiveness, its impact on inflammatory markers and recovery outcomes remains less clearly defined. The neutrophil-to-lymphocyte ratio (NLR) is used as a readily available, cost-effective biomarker of systemic inflammation. This study retrospectively analyzes perioperative data from patients who underwent tympanoplasty or myringoplasty, comparing NLR levels, intraoperative vital signs, and postoperative recovery parameters between low-flow and high-flow anesthesia groups. The results may contribute to optimizing anesthetic strategies in otologic surgeries, with emphasis on inflammation modulation and patient safety.
Interventions
None listed
Sponsors
Eda KAZANÇ ÖZDEN
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged between 18 and 75 years * American Society of Anesthesiologists (ASA) physical status classification I to III * Body Mass Index (BMI) between 18.5 and 29.9 kg/m²
Exclusion criteria
* Age below 18 or above 75 years * Incomplete or missing clinical data * BMI less than 18.5 kg/m² or greater than 29.9 kg/m² * Presence of neurological disorders * History of renal or hepatic failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative neutrophil-to-lymphocyte ratio (NLR) | Within 1 hour postoperatively (Day 0) | The neutrophil-to-lymphocyte ratio measured from blood samples taken immediately after surgery to assess the systemic inflammatory response in patients undergoing tympanoplasty or myringoplasty with low-flow or high-flow anesthesia. |
Countries
Turkey (Türkiye)
Outcome results
None listed